Slate
Blackcurrant
Watermelon
Strawberry
Orange
Banana
Apple
Emerald
Chocolate
Marble
Slate
Blackcurrant
Watermelon
Strawberry
Orange
Banana
Apple
Emerald
Chocolate
Marble
All Activity
This stream auto-updates
- Past hour
-
Amy Turk
- Today
-
Yeah, they have to be 'fair.' No winners and no losers. Pffftt!! The new Broncos mascot.
-
My old buddy, The Admiral.
-
Excitement around hydroxychloroquine for treating COVID-19 causes challenges for rheumatology Brian Owens Published:April 01, 2020DOI:https://doi.org/10.1016/S2665-9913(20)30089-8 Excitement about a potential new treatment for the coronavirus disease 2019 (COVID-19) pandemic currently engulfing the world is causing problems for patients with arthritis and systemic lupus erythematosus (SLE), who routinely use the drug to control their symptoms. The antimalarial drug chloroquine and its safer derivative hydroxychloroquine have been used since the 1940s to treat autoimmune disorders, says Thomas Dörner, a rheumatologist at the Charité University Hospital in Berlin. Though the drug is rarely used for rheumatoid arthritis, around two-thirds of patients with SLE in Europe use hydroxychloroquine to manage their symptoms, and it is the only known therapy so far for primary Sjögren's syndrome, he says. • View related content for this article But the drug has also attracted attention over the past few decades as a potential antiviral agent, currently as a possible treatment for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19. Reports from China found that chloroquine could inhibit SARS-CoV-2 in vitro, and showed apparent efficacy in treating COVID-19 in humans. A small non-randomised trial in France also found hydroxychloroquine to be a promising potential treatment. The findings have prompted many, including US President Donald Trump, to tout hydroxychloroquine as a game-changer in the fight against COVID-19. The US Food and Drug Administration has designated hydroxychloroquine for off-label, compassionate use for treating COVID-19, and WHO added the drug to its large global SOLIDARITY trial to test a variety of potential treatments. But virologists and infectious disease experts caution that the excitement is premature. “Whether hydroxychloroquine works in vivo is not proven for any virus, and in fact in randomised controlled trials against a number of viruses, including influenza, it doesn't work at all,” says Douglas Richman, a virologist and infectious disease physician at the University of California, San Diego. “It's my personal prejudice that this is also going to be the case with coronavirus.” Hydroxychloroquine has been studied as a possible antiviral for approximately the past 40 years, says Richman. The mechanism of action is not entirely clear, but it is known to decrease the acidity in endosomes, which might prevent the endosome from releasing the virus into the cytoplasm. Hydroxychloroquine has shown activity in vitro against many viruses, including influenza and coronaviruses, but that has largely failed to translate into success in either animals or humans. In 2005, the drug showed in vitro activity against SARS-CoV, which is closely related to the current pandemic virus, but it failed to decrease viral load in mice, and clinical interest drifted away, says Christopher Tignanelli, a surgeon at the University of Minnesota in Minneapolis, who is involved in clinical trials of COVID-19 treatments. “There is not a huge amount of pre-clinical data for this drug,” says Tignanelli. “It's mostly test-tube and anecdote.” Despite the absence of strong evidence, some people are already attempting to self-medicate with the drug, with disastrous consequences. Hydroxychloroquine can have dangerous side-effects if the dose is not carefully controlled, and cases of chloroquine poisoning have been reported in Nigeria and the USA. Additionally, the sudden interest in hydroxychloroquine has led to reports of shortages for patients who rely on the drug to treat their autoimmune disease. Kaiser Permanente, a major health-care network in the USA, is no longer filling routine prescriptions for chloroquine. “It's a challenge for us and for our patients,” says Dörner. “When I write a prescription now, I tell my patients that they might need to go to several pharmacies before they get it filled.” The Lupus Foundation of America has called on drug manufacturers to increase the production of hydroxychloroquine, to ensure that patients with SLE who need the medication will still be able to access it while it is being investigated for COVID-19. “For many people with lupus there are no alternatives to these medications,” the Foundation said in a statement. Although the existing evidence is thin, it is promising enough to warrant further study, says David Boulware, an infectious disease physician at the University of Minnesota in Minneapolis. “When someone is sick in hospital, we throw the kitchen sink at them, but we don't always know if it works,” he says. “That's why we need clinical trials.” Boulware is leading a trial to investigate whether hydroxychloroquine could be efficacious as a post-exposure prophylactic to prevent the development of the disease, and to prevent progression of the disease to avoid admission to hospital. The trial (NCT04308668) has already enrolled around 25% of its subjects. Initial results are expected within 3–4 weeks. Though he is skeptical of its efficacy, Richman fully supports further research to establish whether hydroxychloroquine is a good option for treating COVID-19. “It's imperative that good RCTs are implemented to get answers one way or another,” he says.
-
37.5 minutes, to be exact 😉 6th-longest version. It is indeed a good one. My pleasure! '77 seems to get a lot of mileage on here (not complaining), so I thought I'd give '75 some love seeing as it was its time of year...
-
If Bonzo Never Passed Away What Music Would Zeppelin Create?
Brigante replied to JMGuitar's topic in Led Zeppelin Newbies
Jimmy once said that 'Bonzo and I had already started discussing plans for a hard-driving rock album’ after In Through The Out Door. He also said of All My Love that ‘I would not have wanted to pursue that direction in the future.’ So there's clues there about both what he did and didn't want to do next. -
Update: Per Dr. Michael Savage today, he majored in epidemiology.
-
Gee, I wonder where anyone would get that notion from? Yes, I think the west would be well served to bring some public floggings into it's culture for some of the more idiotic behaviours like wanton vandalism and other really shit social behaviours. Make the price to pay patently not worth it. The Hitch said it best. Religion actually does poison everything. NOTHING in this world is improved by the introduction of religion to it. No situation, no discussion or position on morals or values or ethics, nothing. And I'm with you PFY, there seems to be something more to this existance (or beyond it) - more than meets our meagre eyes in my view. The various "Churches" are just institutions like any other. They exist to serve themselves and to ensure they profit and survive. Nothing to do with an individuals relationship to the devine - just a perversion of that concept. Nothing more.
-
...and away we go... Coronabonds Could Save Europe, or Sink It (April 2020) It’s too bad the European Union is talking about “euro bonds 2.0” again, when it should be talking about “Hamilton bonds.” https://www.bloomberg.com/opinion/articles/2020-04-02/coronavirus-coronabonds-could-save-europe-or-sink-it
-
"March 19 - Vancouver -- The 5/24/75 Dazed was my introduction to live Zepp, but I'm pretty sure this was the first full show I listened to. Other shows (like the two above it) might have slightly higher peaks, but this one is just rock-solid, good to great versions all the way through, including my all-time favourite version of "The Rain Song." One of the coolest, best, most concise (22 minutes and change) versions of "No Quarter" as well. It helps that it's probably THE best sounding soundboard of them all. ..." This one really grows on me. Maybe the best D and C of 75. Jimmy's guitar is consistently good throughout. And Jonsey's bass is so clear and prominent. What a fine player he was. For the band in this half hour plus - Not an off moment in the whole. Thanks for posting the topic so I could relisten to this great show.
-
Chinese companies sell ‘coronavirus bonds’ to boost balance sheets (Feb 2020) https://www.ft.com/content/bc394d62-5212-11ea-8841-482eed0038b1 Coronavirus: RBA to buy government bonds to dodge recession (Mar 2020) The Reserve Bank made two extraordinary moves today, firing its last bullets in an attempt to pull our economy back from the brink of recession. https://www.news.com.au/finance/economy/australian-economy/coronavirus-rba-to-buy-government-bonds-to-dodge-recession/news-story/923705e7d0e691fc23c47bc45e5359fe
-
I have no doubt this guy killed himself because he knows what a disaster the IMF's policy "solutions" will be. Last I heard, they are floating the idea of "Coronavirus Bonds". https://www.nydailynews.com/news/world/ny-german-finance-minister-commits-suicide-coronavirus-economy-20200329-bnrvo77ulnd7pcmwhiq5tzpexi-story.html
-
Led Zeppelin Reunion With no (Page) or no (Plant)
Canadianzepper replied to JMGuitar's topic in Musician's Corner
There will never be a Zeppelin reunion. That said, of the three living members, Page is Zeppelin. It will always be that way. What fans feel is what he felt and continues to feel. It was his baby that he would jump in front of a train to protect. -
Probably albums in the vein of "We're Gonna Groove", "Darlene" with a single power song in the mold of Achilles Last Stand (with less flair) on each album, assuming Page could stay on track. I would assume much more input from JPJ and a more mellow, time driven based by Bonzo, his power days behind him. With the advent of heavy keyboard music in Europe in the 1980's, it would have been interesting to see if Zeppelin tried to outdo the other bands at their own game. Just because they can. Alas, all left to conjecture at this point and at that point. RIP JHB.
-
Let her jump off the cliff first. Of course, she probably has bat wings.
-
Must save face, Joe.
-
I have tried to order from Japan this week but failed. Due to the Corona crisis it is not possible to ship to certain European countries via EMS and airmail.
-
- Yesterday
-
If Bonzo Never Passed Away What Music Would Zeppelin Create?
John M replied to JMGuitar's topic in Led Zeppelin Newbies
Two of the most Zeppelin of the post Zeppelin tracks to my ears, probably because each features two of them. -
Cool spoken intro by Jones
-
One of the side effects of hydroxychloroquine is that it increases the normally low pH in the endosomes. Endosomes are where viruses enter cells. For viruses to successfully enter the cells to infect them, they need a low pH (slightly acidic) environment. As hydroxychloroquine increases the pH, the medicine inhibits the virus infecting the cell. Hydroxychloroquine also reduces the replication of the virus. It achieves this feat by increasing the pH in another part of the cell, called the Lysosome. Increasing the pH in the Lysosome reduces the replication of COVID-19. This means the virus is unable to replicate in the cells, which is another mechanism by which hydroxychloroquine benefits the COVID-19 sufferer.
-
Just between us, Japan's numbers (below 2,000) are astonishingly low because they are testing virtually no one. I doubt Tokyo will become as bad as New York City, but it's gonna get a lot worse here soon.
-
Ms. Lagarde is not an economist and she has little direct monetary policy experience. Soon after becoming French finance minister in 2007, Ms. Lagarde was dubbed “Madame la Gaffe” when her plain-speaking style landed her in political hot water. This is the European Central Bank leadership you get when the selection is made based upon "diversity and inclusion" as opposed to real qualifications.
-
Hey Hey What Can I Do - Closing Zep III
kirchzep27 replied to 1998giventofly's topic in Led Zeppelin Master Forum
^Speaking of the weird world of led zep, hey hey and travelling riverside and poor tom have the same element of fun that was very clear early on for them, cause they were so good together. Its totally there on the songs page and bonzo did with lord such also. Yet that light hearted element is implemented very sparingly throughout all of the records, good times, living loving, dancing days, crunge, ocean, mmh, candystore, hots on, southbound, fool So i totally agree that hey hey, should have been on 3, it would have totally made that record more memorable, accessible. Also, now that i think about it, it does have a end of movie, credits rolling aspect that would work as a closing song. Yet with that, i would suggest another upbeat song like travellin riverside and an edit of an acoustic song or 2 . -
Picked up an eelgrass 6 cd copy of 9/28 for $71, plus shipping. Haven’t received it yet...
